Analysis of a complex chemical compound
On the basis of the chemical principle of carbonic anhydrase (CA)-aromatic sulfonamide inhibitor interaction, a dansylamidoethyl-pendant cyclen(1-(2-(5-(dimethylamino)-1-naphthalenesulfonamido)ethyl)-1,4,7,10-tetraazacyclododecane, HL) was synthesized as a novel type of zinc(II)-fluorophore. The new ligand forms very stable complexes with zinc(II), cadmium(II), and copper(II) at physiological pH. The X-ray crystal study of the Zn complex disclosed a five-coordinate, distorted square-pyramidal structure with the deprotonated dansylamide N-coordinating at the apical site.



Biokémia